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Nom : MORLAIS
Prénom : Isabelle
Equipe : EEPI
Grade : DR2
Adresse email : Cette adresse e-mail est protégée contre les robots spammeurs. Vous devez activer le JavaScript pour la visualiser.
Téléphone : (+33) 4 67 41 63 21
Bureau : 131
Implantation : IRD Montpellier
Appartenance : IRD

Publications :

Gendrin M, Turlure F, Rodgers FH, Cohuet A, Morlais I, Christophides GK (2017) The peptidoglycan recognition proteins PGRPLA and PGRPLB regulate Anopheles immunity to bacteria and affect infection by Plasmodium. Journal of Innate Immunity 9: 333-342 doi

Eldering M, Morlais I, van Gemert GJ, van de Vegte-Bolmer M, Graumans W, Siebelink-Stoter R, Vos M, Abate L, Roeffen W, Bousema T, Levashina EA, Sauerwein RW (2016) Variation in susceptibility of African Plasmodium falciparum malaria parasites to TEP1 mediated killing in Anopheles gambiae mosquitoes. Scientific Reports 6: 20440 doi

Menard S, Tchoufack JN, Maffo CN, Nsango SE, Iriart X, Abate L, Tchioffo MT, Awono-Ambéné PH, Mekongo FAA, Morlais I, Berry (2016) Insight into k13-propeller gene polymorphism and ex vivo DHA-response profiles from Cameroonian isolates. Malaria Journal 15: 572 doi

Sandeu MM, Abate L, Tchioffo MT, Bayibéki AN, Awono-Ambéné PH, Nsango SE, Chesnais CB, Dinglasan RR, de Meeûs T, Morlais I (2016) Impact of exposure to mosquito transmission-blocking antibodies on Plasmodium falciparum population genetic structure. Infection, Genetics and Evolution 45: 138-144 doi

Tchioffo MT, Abate L, Boissière A, Nsango SE, Gimonneau G, Berry A, Oswald E, Dubois D, Morlais I (2016) An epidemiologically successful Escherichia coli sequence type modulates Plasmodium falciparum infection in the mosquito midgut. Infection, Genetics and Evolution 43: 22-30 doi

Tchioffo MT, Boissière A, Abate L, Nsango SE, Bayibéki AN, Awono-Ambéné PH, Christen R, Gimonneau G, Morlais I (2016) Dynamics of bacterial community composition in the malaria mosquito's epithelia. Frontiers in Microbiology 6: 1500 doi

Chauvin P, Menard S, Iriart X, Nsango SE, Tchioffo MT, Abate L, Awono-Ambene PH, Morlais I, Berry A (2015) Prevalence of Plasmodium falciparum parasites resistant to sulfadoxine/pyrimethamine in pregnant women in Yaoundé, Cameroon: emergence of highly resistant pfdhfr/pfdhps alleles. Journal of Antimicrobial Chemotherapy 70: 2566-2571 doi

Morlais I, Nsango SE, Toussile W, Abate L, Annan Z, Tchioffo MT, Cohuet A, Awono-Ambene PH, Fontenille D, Rousset F, Berry A (2015) Plasmodium falciparum mating patterns and mosquito infectivity of natural isolates of gametocytes. PLoS One 10: e0123777 doi

Gimonneau G, Tchioffo MT, Abate L, Boissiere A, Awono-Ambene PH, Nsango SE, Christen R & Morlais I (2014) Composition of Anopheles coluzzii and Anopheles gambiae microbiota from larval to adult stages. Infection, Genetics and Evolution. 28: 715-724 doi

Marie A, Holzmuller P, Tchioffo MT, Rossignol M, Demettre E, Seveno M, Corbel V, Awono-Ambene P, Morlais I, Remoué F & Cornelie S (2014) Anopheles gambiae salivary protein expression modulated by wild Plasmodium falciparum infection: highlighting of new antigenic peptides as candidates of An. gambiae bites. Parasites & Vectors. 7: 599 doi

Boissière A, Gimonneau G, Tchioffo MT, Abate L, Bayibeki A, Awono-Ambéné PH, Nsango SE & Morlais I (2013) Application of a qPCR Assay in the investigation of susceptibility to malaria infection of the M and S molecular forms of An. gambiae s.s. in Cameroon. PLoS One. 8: e54820 doi

Bousema T, Churcher TS, Morlais I & Dinglasan RR (2013) Can field-based mosquito feeding assays be used for evaluating transmission-blocking interventions? Trends in Parasitology. 29: 53-59 doi

Marie A, Boissière A, Tchioffo MT, Poinsignon A, Awono-Ambéné PH, Morlais I, Remoué F & Cornelie S (2013) Evaluation of a real-time quantitative PCR to measure the wild Plasmodium falciparum infectivity rate in salivary glands of Anopheles gambiae. Malaria Journal. 12: 224 doi

Ndo C, Simard F, Kengne P, Awono-Ambene P, Morlais I, Sharakhov I, Fontenille D & Antonio-Nkondjio C (2013) Cryptic genetic diversity within the Anopheles nili group of malaria vectors in the equatorial forest area of Cameroon (Central Africa). PLoS One. 8: e58862 doi

Nsango SE, Pompon J, Xie T, Rademacher A, Fraiture M, Thoma M, Awono-Ambene PH, Moyou RS, Morlais I & Levashina EA (2013) AP-1/Fos-TGase2 axis mediates wounding-induced Plasmodium falciparum killing in Anopheles gambiae. Journal of Biological Chemistry. 288: 16145-16154 doi

Sangare I, Michalakis Y, Yameogo B, Dabire R, Morlais I & Cohuet A (2013) Studying fitness cost of Plasmodium falciparum infection in malaria vectors: validation of an appropriate negative control. Malaria Journal. 12: 2 doi

Tchioffo MT, Boissière A, Churcher TS, Abate L, Gimonneau G, Nsango SE, Awono-Ambene PH, Christen R, Berry A & Morlais I (2013) Modulation of malaria infection in Anopheles gambiae mosquitoes exposed to natural midgut bacteria. PLoS One. 8: e81663 doi

Boissière A, Tchioffo MT, Bachar D, Abate L, Marie A, Nsango SE, Shahbazkia HR, Awono-Ambene PH, Levashina EA, Christen R & Morlais I (2012) Midgut microbiota of the malaria mosquito vector Anopheles gambiae and interactions with Plasmodium falciparum infection. PLoS Pathogens. 8: e1002742 doi

Bousema T, Dinglasan RR, Morlais I, Gouagna LC, van Warmerdam T, Awono-Ambene PH, Bonnet S, Diallo M, Coulibaly M, Tchuinkam T, Mulder B, Targett G, Drakeley C, Sutherland C, Robert V, Doumbo O, Toure Y, Graves PM, Roeffen W, Sauerwein R, Birkett A, Locke E, Morin M, Wu YM & Churcher TS (2012) Mosquito feeding assays to determine the infectiousness of naturally infected Plasmodium falciparum gametocyte carriers. PLoS One. 7: e42821 doi

Harris C, Morlais I, Churcher TS, Awono-Ambene P, Gouagna LC, Dabire RK, Fontenille D & Cohuet A (2012) Plasmodium falciparum produce lower infection intensities in local versus foreign Anopheles gambiae populations. PLoS One. 7: e30849 doi

Mancini E, Baldini F, Tammaro F, Calzetta M, Serrao A, George P, Morlais I, Masiga D, Sharakhov IV, Rogers DW, Catteruccia F & della Torre A (2011) Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector Anopheles gambiae. BMC Evolutionary Biology. 11: 292 doi

Menard S, Morlais I, Tahar R, Sayang C, Mayengue PI, Iriart X, Benoit-Vical F, Lemen B, Magnaval JF, Awono-Ambene P, Basco LK & Berry A (2012) Molecular monitoring of Plasmodium falciparum drug susceptibility at the time of the introduction of artemisinin-based combination therapy in Yaounde, Cameroon: Implications for the future. Malaria Journal. 11: 113 doi

Nsango SE, Abate L, Thoma M, Pompon J, Fraiture M, Rademacher A, Berry A, Awono-Ambene PH, Levashina EA & Morlais I (2012) Genetic clonality of Plasmodium falciparum affects the outcome of infection in Anopheles gambiae. International Journal for Parasitology. 42: 589-595 doi

Mancini E, Baldini F, Tammaro F, Calzetta M, Serrao A, George P, Morlais I, Masiga D, Sharakhov IV, Rogers DW, Catteruccia F & della Torre A (2011) Molecular characterization and evolution of a gene family encoding male-specific reproductive proteins in the African malaria vector Anopheles gambiae. BMC Evolutionary Biology. 11: 292 doi

Mendes AM, Awono-Ambene PH, Nsango SE, Cohuet A, Fontenille D, Kafatos FC, Christophides GK, Morlais I & Vlachou D (2011) Infection intensity-dependent responses of Anopheles gambiae to the African malaria parasite Plasmodium falciparum. Infection and Immunity. 79: 4708-4715 doi

Rottschaefer SM, Riehle MM, Coulibaly B, Sacko M, Niare O, Morlais I, Traore SF, Vernick KD & Lazzaro BP (2011) Exceptional diversity, maintenance of polymorphism, and recent directional selection on the APL1 malaria resistance genes of Anopheles gambiae. PLoS Biology. 9: e1000600 doi

Harris C, Lambrechts L, Rousset F, Abate L, Nsango SE, Fontenille D, Morlais I & Cohuet A (2010) Polymorphisms in Anopheles gambiae immune genes associated with natural resistance to Plasmodium falciparum. PLoS Pathogens. 6: e1001112

Harris C, Rousset F, Morlais I, Fontenille D & Cohuet A (2010) Low linkage disequilibrium in wild Anopheles gambiae s.l. populations. BMC Genetics. 11: 81

Ndo C, Antonio-Nkondjio C, Cohuet A, Ayala D, Kengne P, Morlais I, Awono-Ambene PH, Couret D, Ngassam P, Fontenille D & Simard F (2010) Population genetic structure of the malaria vector Anopheles nili in sub-Saharan Africa. Malaria Journal. 9: 161

Etang J, Vicente JL, Nwane P, Chouaibou M, Morlais I, Do Rosario VE, Simard F, Awono-Ambene P, Toto JC & Pinto J (2009) Polymorphism of intron-1 in the voltage-gated sodium channel gene of Anopheles gambiae s.s. populations from Cameroon with emphasis on insecticide knockdown resistance mutations. Molecular Ecology. 18: 3076-3086

Meister S, Agianian B, Turlure F, Relogio A, Morlais I, Kafatos FC & Christophides GK (2009) Anopheles gambiae PGRPLC-mediated defense against bacteria modulates infections with malaria parasites. PLoS Pathogens. 5: e1000542 pdf

Mitri C, Jacques JC, Thiery I, Riehle MM, Xu J, Bischoff E, Morlais I, Nsango SE, Vernick KD & Bourgouin C (2009) Fine pathogen discrimination within the APL1 gene family protects Anopheles gambiae against human and rodent malaria species. PLoS Pathogens. 5: e1000576 pdf

Cohuet A, Krishnakumar S, Simard F, Morlais I, Koutsos A, Fontenille D, Mindrinos M & Kafatos FC (2008) SNP discovery and molecular evolution in Anopheles gambiae, with special emphasis on innate immune system. BMC Genomics. 9: 227

Mendes AM, Schlegelmilch T, Cohuet A, Awono-Ambene P, De Iorio M, Fontenille D, Morlais I, Christophides GK, Kafatos FC & Vlachou D (2008) Conserved mosquito/parasite interactions affect development of Plasmodium falciparum in Africa. PLoS Pathogens. 4: e1000069 pdf

Ribaut C, Berry A, Chevalley S, Reybier K, Morlais I, Parzy D, Nepveu F, Benoit-Vical F & Valentin A (2008) Concentration and purification by magnetic separation of the erythrocytic stages of all human Plasmodium species. Malaria Journal. 7: 45 pdf

Riehle MM, Xu JN, Lazzaro BP, Rottschaefer SM, Coulibaly B, Sacko M, Niare O, Morlais I, Traore SF & Vernick KD (2008) Anopheles gambiae APL1 is a family of variable LRR proteins required for Rel1-mediated protection from the malaria parasite, Plasmodium berghei. PLoS One. 3: 8

Lambrechts L, Morlais I, Awono Ambene P, Cohuet A, Simard F, Jacques JC, Bourgouin C & Koella JC (2007) Effect of infection by Plasmodium falciparum on the melanization immune response of Anopheles gambiae. American Journal of Tropical Medicine and Hygiene. 76: 475-480 pdf

Cohuet A, Osta M, Morlais I, Awono Ambene P, Michel K, Simard F, Christophides G, Fontenille D & Kafatos F (2006) Anopheles and Plasmodium: from laboratory models to natural systems in the field. EMBO Reports. 7: 1285-1289 pdf

Etang J, Fondjo E, Chandre F, Morlais I, Brengues C, Nwane P, Chouaibou M, Ndjemai H & Simard F (2006) First report of knockdown mutations in the malaria vector Anopheles gambiae from Cameroon. American Journal of Tropical Medicine and Hygiene. 74: 795-797 pdf

Michel K, Suwanchaichinda C, Morlais I, Lambrechts L, Cohuet A, Awono Ambene P, Simard F, Fontenille D, Kanost MR & Kafatos F (2006) Increased melanizing activity in Anopheles gambiae does not affect development of Plasmodium falciparum. Proceedings of the National Academy of Sciences USA. 103: 16858-16863 pdf

Michel K, Suwanchaichinda C, Morlais I, Lambrechts L, Cohuet A, Awono-Ambene PH, Simard F, Fontenille D, Kanost MR & Kafatos FC (2006) Increased melanizing activity in Anopheles gambiae does not inhibit Plasmodium falciparum development. Proceedings of the National Academy of Sciences USA. 103: 16858-16863

Morlais I, Girod R, Hunt RH, Simard F & Fontenille D (2005) Population structure of Anopheles arabiensis on la réunion Island, Indian ocean. American Journal of Tropical Medicine and Hygiene. 73: 1077-1082 pdf

Morlais I, Poncon N, Simard F, Cohuet A & Fontenille D (2004) Intraspecific nucleotide variation in Anopheles gambiae: new insights into the biology of malaria vectors. American Journal of Tropical Medicine and Hygiene. 71: 795-802 pdf

Severson DW, DeBruyn B, Lovin DD, Brown SE, Knudson DL & Morlais I (2004) Comparative genome analysis of the yellow fever mosquito Aedes aegypti with Drosophila melanogaster and the malaria vector mosquito Anopheles gambiae. Journal of Heredity. 95: 103-113 pdf

Chippaux JP, Bouchite B, Demanou M, Morlais I & Le Goff G (2000) Density and dispersal of the loaiasis vector Chrysops dimidiata in southern Cameroon. Medical and Veterinary Entomology. 14: 339-344