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This team led by This email address is being protected from spambots. You need JavaScript enabled to view it. is developing molecular and cellular biology and functional genomics approaches in several parasitic protozoa, mainly the Trypanosomatidae Leishmania (responsible for leishmaniasis) and Trypanosoma brucei (agent of sleeping sickness).

Availability of complete genome sequences of these parasites, combined with the most recent technological developments have made possible to explore the major nuclear and chromosomal functions (segregation, replication, recombination, etc.) and vital cellular processes (mitosis, mobility, transport intracellular ...) in these 'divergent' eukaryotes.

The general objective of this research is to understand the entanglement of these different processes during the cell cycle and their importance in the life cycle of the parasite, as well as in virulence, adaptation to the environment or resistance to anti- parasitic drugs.

The team was the first to implement the CRISPR-Cas9 system in Leishmania (Sollelis et al. Cell Microbiol 2015) and more recently to develop an inducible KO system combining CRISPR-Cas9 and Di-CRE (Yagoubat et al. Cell Microbiol 2020). Request the plasmidsThis email address is being protected from spambots. You need JavaScript enabled to view it..

This team is located in the Montpellier University Hospital Center which has led to fruitful interactions between hospital practitioners, teacher-researchers and researchers from different environments, and has also favored other translational studies focused on the molecular diagnosis of toxoplamosis and leishmaniasis. As such, several members of the team are part of the National Reference Center for Leishmaniases and / or of the "Molecular Biology" Pole of the National Reference Center for Toxoplasmosis.  

Permanent/long-term members of the group:

Publications of BioGEPPE