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III. Equipe  "Pathologie des Pathogènes Eucaryotes"

 

réalise une recherche "translationnelle" concernant le diagnostic, l'identification, l'épidémiologie et la pathologie des parasites et champignons en santé humaine. Des études sont particulièrement développées sur : l’épidémiologie de mycoses pulmonaires dues à des Basidiomycetes, et l’amélioration de la prévention des mycoses invasives par l’évaluation d’un score pronostique "statut Candida" qui permet de détecter très précocement les patients à haut risque. La plupart des travaux sont menés en collaboration avec le CHU de Nîmes, mais un réseau de collaborations au niveau national a aussi été mis en place, regroupant une dizaine d’équipes hospitalo-universitaires. Par ailleurs, une activité d’identification des espèces de Leishmania par MALDI-TOF a été développée avec la création d’une base de données qui est en cours d’évolution. Ce travail est un partenariat entre l’équipe du Pr Magalie Demar de l’équipe EA 3593, EPaT Ecosystèmes Amazoniens et Pathologie Tropicale, Université de Guyane, et le Pr Renaud Piarroux de la Pitié-Salpêtrière à Paris

Membres de l'équipe

Publications 'MiVEGEC' par membres de l'équipe depuis 2005 :

| 2005 | | 2008 | | 2009 | | 2010 | | 2011 | | 2012 | | 2013 | | 2014 | | 2015 | | 2016 | | 2017 | | 2018 | | 2019 |

2019

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Leveque MF, Chiffre D, Galtier C, Albaba S, Ravel C, Lachaud L, Iemmi A, Flori P, Sterkers Y (2019) Molecular diagnosis of toxoplasmosis at the onset of symptomatic primary infection: a straightforward alternative to serological examinations. International Journal of Infectious Diseases 79: 131-133 doi

2018

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Jaber HT, Hailu A, Pratlong F, Lami P, Bastien P, Jaffe CL (2018) Analysis of genetic polymorphisms and tropism in east African Leishmania donovani by amplified fragment length polymorphism and kDNA minicircle sequencing. Infection, Genetics and Evolution 65: 80-90 doi

2017

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Lachaud L, Fernandez-Arevalo A, Normand AC, Lami P, Nabet C, Donnadieu JL, Piarroux M, Djenad F, Cassagne C, Ravel C, Tebar S, Llovet T, Blanchet D, Demar M, Harrat Z, Aoun K, Bastien P, Munoz C, Gallego M, Piarroux R (2017) Identification of Leishmania by matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry using a free web-based application and a dedicated mass-spectral library. Journal of Clinical Microbiology 55: 2924-2933 doi

Pigott DM, Golding N, Messina JP, Battle KE, Duda KA, Balard Y, Bastien P, Pratlong F, Brownstein JS, Freifeld CC, Mekaru SR, Madoff LC, George DB, Myers MF, Hay SI (2014) Global database of leishmaniasis occurrence locations, 1960-2012. Scientific Data 1: 140036 doi

2016

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El Safadi D, Cian A, Nourrisson C, Pereira B, Morelle C, Bastien P, Bellanger AP, Botterel F, Candolfi E, Desoubeaux G, Lachaud L, Morio F, Pomares C, Rabodonirina M, Wawrzyniak I, Delbac F, Gantois N, Certad G, Delhaes L, Poirier P, Viscogliosi E (2016) Prevalence, risk factors for infection and subtype distribution of the intestinal parasite Blastocystis sp from a large-scale multi-center study in France. BMC Infectious Diseases 16: 451 doi

Pratlong F, Balard Y, Lami P, Talignani L, Ravel C, Dereure J, Lefebvre M, Serres G, Bastien P, Dedet JP (2016) The Montpellier Leishmania collection, from a laboratory collection to a biological resource center: a 39-year-long story. Biopreservation and Biobanking 14: 470-479 doi

Stanojcic S, Sollelis L, Kuk N, Crobu L, Balard Y, Schwob E, Bastien P, Pagès M, Sterkers Y (2016) Single-molecule analysis of DNA replication reveals novel features in the divergent eukaryotes Leishmania and Trypanosoma brucei versus mammalian cells. Scientific Reports 6: 23142 doi

Tetaud E, Lefebvre M, M'Bang-Benet DE, Crobu L, Blancard C, Sterkers Y, Pagès M, Bastien P, Merlin G (2016) TbFlabarin, a flagellar protein of Trypanosoma brucei, highlights differences between Leishmania and Trypanosoma flagellar-targeting signals. Experimental Parasitology 166: 97-107 doi

2015

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Chaara D, Bañuls AL, Haouas N, Talignani L, Lami P, Mezhoud H, Harrat Z, Dedet JP, Babba H, Pratlong F (2015) Comparison of Leishmania killicki (syn. L. tropica) and Leishmania tropica population structure in Maghreb by microsatellite typing. PLoS Neglected Tropical Diseases 9: e0004204 doi

Chaara D, Ravel C, Bañuls AL, Haouas N, Lami P, Talignani L, El Baidouri F, Jaouadi K, Harrat Z, Dedet JP, Babba H & Pratlong F (2015) Evolutionary history of Leishmania killicki (synonymous Leishmania tropica) and taxonomic implications. Parasites & Vectors. 8 doi

Morelle C, Sterkers Y, Crobu L, Mbang-Benet DE, Kuk N, Portales P, Bastien P, Pagès M, Lachaud L (2015) The nucleoporin Mlp2 is involved in chromosomal distribution during mitosis in trypanosomatids. Nucleic Acids Research 43: 4013-4027 doi

2014

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Bourgeois N, Laurens C, Bertout S, Balard Y, Krasteva D, Rispail P & Lachaud L (2014) Assessment of caspofungin susceptibility of Candida glabrata by the Etest (R), CLSI, and EUCAST methods, and detection of FKS1 and FKS2 mutations. European Journal of Clinical Microbiology & Infectious Diseases. 33: 1247-1252 doi

Brengues C, Ferre JB, Le Goff G, Lami P, Pratlong F, Pasteur N, Lagneau C, Simard F & Robert V (2014) A multiplex PCR to differentiate the two sibling species of mosquitoes Ochlerotatus detritus and Oc. coluzzii and evidence for further genetic heterogeneity within the Detritus complex. Infection, Genetics and Evolution. 28: 676-680 doi

Lachaud L, Bourgeois N, Kuk N, Morelle C, Crobu L, Merlin G, Bastien P, Pagès M & Sterkers Y (2014) Constitutive mosaic aneuploidy is a unique genetic feature widespread in the Leishmania genus. Microbes and Infection. 16: 61-66 doi

Pigott DM, Bhatt S, Golding N, Duda KA, Battle KE, Brady OJ, Messina JP, Balard Y, Bastien P, Pratlong F, Brownstein JS, Freifeld C, Mekaru SR, Gething PW, George DB, Myers MF, Reithinger R & Hay SI (2014) Global distribution maps of the Leishmaniases. Elife. 3: e02851 doi

Sterkers Y, Crobu L, Lachaud L, Pagès M & Bastien P (2014) Parasexuality and mosaic aneuploidy in Leishmania: alternative genetics. Trends in Parasitology. 30: 429-435 doi

2013

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Dedet JP, Carme B, Desbois N, Bourdoiseau G, Lachaud L & Pratlong F (2013) Epidemiology of autochthonous leishmaniases in France. Presse Medicale. 42: 1469-1481

Lachaud L, Dedet JP, Marty P, Faraut F, Buffet P, Gangneux JP, Ravel C, Bastien P & the working group for the notification of human leishmanioses in France (2013) Surveillance of leishmaniases in France, 1999 to 2012. Eurosurveillance. 18: 38-44

Lefebvre M, Tetaud E, Thonnus M, Salin B, Boissier F, Blancard C, Sauvanet C, Metzler C, Espiau B, Sahin A & Merlin G (2013) LdFlabarin, a new BAR domain membrane protein of Leishmania flagellum. PLoS One. 8: 76380 doi

Morizot G, Kendjo E, Mouri O, Thellier M, Perignon A, Foulet F, Cordoliani F, Bourrat E, Laffitte E, Alcaraz I, Bodak N, Ravel C, Vray M, Grogl M, Mazier D, Caumes E, Lachaud L, Buffet PA & the Cutaneous Leishmaniasis French Study Group (2013) Travelers with cutaneous leishmaniasis cured without systemic therapy. Clinical Infectious Diseases. 57: 370-380 doi

Pratlong F, Lami P, Ravel C, Balard Y, Dereure J, Serres G, El Baidouri F & Dedet JP (2013) Geographical distribution and epidemiological features of Old World Leishmania infantum and Leishmania donovani foci, based on the isoenzyme analysis of 2277 strains. Parasitology. 140: 423-434 doi

2012

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Ait-Oudhia K, Gazanion E, Sereno D, Oury B, Dedet JP, Pratlong F & Lachaud L (2012) In vitro susceptibility to antimonials and amphotericin B of Leishmania infantum strains isolated from dogs in a region lacking drug selection pressure. Veterinary Parasitology. 187: 386-393 doi

Boissiere A, Arnathau C, Duperray C, Berry L, Lachaud L, Renaud F, Durand P & Prugnolle F (2012) Isolation of Plasmodium falciparum by flow-cytometry: implications for single-trophozoite genotyping and parasite DNA purification for whole-genome high-throughput sequencing of archival samples. Malaria Journal. 11: 163 doi

Haouas N, Chaker E, Chargui N, Gorcii M, Belhadj S, Kallel K, Aoun K, Akrout FM, Ben Said M, Pratlong F, Dedet JP, Mezhoud H, Lami P, Zribi M, Azaiez R & Babba H (2012) Geographical distribution updating of Tunisian leishmaniasis foci: About the isoenzymatic analysis of 694 strains. Acta Tropica. 124: 221-228 doi

Libert C, Ravel C, Pratlong F, Lami P, Dereure J & Keck N (2012) Leishmania infantum infection in two captive Barbary lions (Panthera leo leo). Journal of Zoo and Wildlife Medicine. 43: 685-688

Ranque S, Lachaud L, Gari-Toussaint M, Michel-Nguyen A, Mallie M, Gaudart J & Bertout S (2012) Interlaboratory reproducibility of Etest Amphotericin B and Caspofungin yeast susceptibility testing and comparison with the CLSI method. Journal of Clinical Microbiology. 50: 2305-2309 doi

Sterkers Y, Lachaud L, Bourgeois N, Crobu L, Bastien P & Pagès M (2012) Novel insights into genome plasticity in Eukaryotes: mosaic aneuploidy in Leishmania. Molecular Microbiology. 86: 15-23 doi

2011

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Bourgeois N, Douard-Enault C, Reynes J, Lechiche C, Basset D, Rispail P & Lachaud L (2011) Seven imported histoplasmosis cases due to Histoplasma capsulatum var. capsulatum: From few weeks to more than three decades asymptomatic period. Journal de Mycologie Medicale. 21: 19-23 doi

Buffet PA, Rosenthal E, Gangneux JP, Lightburne E, Couppie P, Morizot G, Lachaud L, Marty P & Dedet JP (2011) Therapy of leishmaniasis in France: Consensus on proposed guidelines. Presse Medicale. 40: 173-184 doi

Crouzet J, Sotto A, Picard E, Lachaud L & Bourgeois N (2011) A case of Candida haemulonii osteitis: clinical features, biochemical characteristics, and antifungal resistance profile. Clinical Microbiology and Infection. 17: 1068-1070 doi

Fraisse T, Crouzet J, Lachaud L, Durand A, Charachon S, Lavigne JP & Sotto A (2011) Candiduria in those over 85 years old: a retrospective study of 73 patients. Internal Medicine. 50: 1935-1940 doi

Fraisse T, Lachaud L, Sotto A, Lavigne JP, Cariou G, Boiteux JP, Escaravage L, Coloby P, Bruyere F & le CIAFU (2011) Recommendations of the infectious disease committee of the French Association of Urology. Diagnosis, treatment and monitoring candiduria. Progres en Urologie. 21: 314-321 doi

Gari-Toussaint M, Lachaud L, Pihet M, Rispail P, Castillo L, Crampette L & Bouchara JP (2011) Chronic sinusitis due to Schizophyllum commune. About two new cases. Journal de Mycologie Medicale. 21: 289-293 doi

Sterkers Y, Lachaud L, Crobu L, Bastien P & Pagès M (2011) FISH analysis reveals aneuploidy and continual generation of chromosomal mosaicism in Leishmania major. Cellular Microbiology. 13: 274-283 doi

2010

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Bourgeois N, Bastien P, Reynes J, Makinson A, Rouanet I & Lachaud L (2010) 'Active chronic visceral leishmaniasis' in HIV-1-infected patients demonstrated by biological and clinical long-term follow-up of 10 patients. HIV Medicine. 11: 670-673

Bourgeois N, Boutet A, Bousquet PJ, Basset D, Douard-Enault C, Charachon S & Lachaud L (2010) Comparison of three real-time PCR methods with blood smears and rapid diagnostic test in Plasmodium sp. infection. Clinical Microbiology and Infection. 16: 1305-1311

Bourgeois N, Dehandschoewercker L, Bertout S, Bousquet PJ, Rispail P & Lachaud L (2010) Antifungal Susceptibility of 205 Candida spp. Isolated primarily during invasive candidiasis and comparison of the Vitek 2 System with the CLSI broth microdilution and Etest methods. Journal of Clinical Microbiology. 48: 154-161

Massanet P, Corne P, Conseil M, Perrigault PF, Lachaud L, Jaber S, Calvet B, Jonquet O & Reynes J (2010) Antifungal treatments of candidemia in non-neutropenic patients: Evaluation of practice in intensive care units. Médecine et Maladies Infectieuses. 40: 644-649

2009

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Ait-Oudhia K, Lami P, Lesceu S, Harrat Z, Hamrioui B, Dedet JP & Pratlong F (2009) Increase in the prevalence of canine leishmaniasis in urban Algiers (Algeria) following the 2003 earthquake. Annals of Tropical Medicine and Parasitology. 103: 679-692

Casanova M, Crobu L, Blaineau C, Bourgeois N, Bastien P & Pagès M (2009) Microtubule-severing proteins are involved in flagellar length control and mitosis in Trypanosomatids. Molecular Microbiology. 71: 1353-1370

Chargui N, Amro A, Haouas N, Schonian G, Babba H, Schmidt S, Ravel C, Lefebvre M, Bastien P, Chaker E, Aoun K, Zribi M & Kuhls K (2009) Population structure of Tunisian Leishmania infantum and evidence for the existence of hybrids and gene flow between genetically different populations. International Journal for Parasitology. 39: 801-811

Dereure J, Vanwambeke SO, Male P, Martinez S, Pratlong F, Balard Y & Dedet JP (2009) The potential effects of global warming on changes in canine leishmaniasis in a focus outside the classical area of the disease in southern France. Vector-Borne and Zoonotic Diseases. 9: 687-694

Lachaud L, Bourgeois N, Plourde M, Leprohon P, Bastien P & Ouellette M (2009) Parasite susceptibility to Amphotericin B in failures of treatment for visceral leishmaniasis in patients coinfected with HIV Type 1 and Leishmania infantum. Clinical Infectious Diseases. 48: E16-E22

Lachaud L, Calas O, Picot MC, Albaba S, Bourgeois N & Pratlong F (2009) Value of 2 IgG avidity commercial tests used alone or in association to date toxoplasmosis contamination. Diagnostic Microbiology and Infectious Disease. 64: 267-274

Pratlong F, Dereure J, Ravel C, Lami P, Balard Y, Serres G, Lanotte G, Rioux JA & Dedet JP (2009) Geographical distribution and epidemiological features of Old World cutaneous leishmaniasis foci, based on the isoenzyme analysis of 1048 strains. Tropical Medicine & International Health. 14: 1071-1085

2008

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Bourgeois N, Lachaud L, Reynes J, Rouanet I, Mahamat A & Bastien P (2008) Long-term monitoring of visceral leishmaniasis in patients with AIDS - Relapse risk factors, value of polymerase chain reaction, and potential impact on secondary prophylaxis. Journal of Acquired Immune Deficiency Syndromes. 48: 13-19

2005

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Basset D, Faraut F, Marty P, Dereure J, Rosenthal E, Mary C, Pratlong F, Lachaud L, Bastien P & Dedet JP (2005) Visceral leishmaniasis in organ transplant recipients: 11 new cases and a review of the literature. Microbes and Infection. 7: 1370-1375